The Centre for Research in Biomolecular Interactions presents guest lecturer, Dr. Baltazar Aguda, Staff Scientist at the Neuro-Oncology Branch, National Cancer Institute, NIH, MD, USA

Qualitative Network Analysis & MicroRNA Regulation of a Cancer Network

I will discuss how qualitative network analysis (qNET) is employed to determine the essential feedback loops in the G1-S transition of the mammalian cell cycle that generate the switching behavior associated with the Restriction Point. This important cell cycle checkpoint is dysregulated in so many human cancers. The qNET analysis focuses on the structure of the interaction network and the identification of destabilizing cycles that potentially cause instability and switching dynamics. The finetuning of the Restriction Point switch by microRNAs (particularly miR-17-92)  will be discussed.

References:
[1]  B D Aguda, A B Goryachev, "From pathways databases to network models of switching behavior", PLoS Comp Biol 3:1674-8N 2007.
[2]  B D Aguda, Y Kim, M G Piper-Hunter, A Friedman, C B Marsh, "MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc", PNAS 105:19678-83 2008.

 

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Refreshments will be served.