Centre for Research on Biomolecular Interactions presents Prof. Andrew Sharrocks, Faculty of Biology, Medicine and Health, University of Manchester, UK

Talk Title: "Transcription factor networks controlling early embryonic stem cell fate transitions"

Abstract: The first cell fate decisions in embryonic stem cells (ESCs) are crucial in establishing subsequent developmental processes. Previously we identified a number of factors involved in the exit of mouse ESCs from the naive ground state to the “primed” epiblast-like state. One of these is the transcription factor Otx2. To identify novel regulators of this transition, we have exploited open chromatin profiling to uncover the dynamically changing regulatory chromatin environment that accompanies this transition. This has led to the identification of Zic transcription factors as key regulators of this transition. In this talk, I will present our currently knowledge of the transcriptional regulatory networks driving the first cell fate changes in ESC differentiation.

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Refreshments will be served.