Centre for Research on Biomolecular Interactions presents Prof. Guoxiong Xu, Center Laboratory at Jinshan Hospital, Fudan University, China.

Short biography: Prof. Guoxiong Xu is a scientist and the director of Center Laboratory at Jinshan Hospital, Fudan University, China. He obtained his medical degree from Shanghai Second Medical University in China, a Master degree in Medical and Pharmaceutical Research from Free University of Brussels in Belgium, and a PhD degree in Biology from York University in Canada. Dr. Xu has published 79 peer-reviewed papers and has obtained 12 Chinese patents. His current research interests focus on the molecular mechanisms of cancer development, chemoresistance, and non-coding RNA. He has served as an editorial board member in International Journal of Oncology, Oncology Reports, and American Journal of Biomedical Research, etc. Dr. Xu instructs a course of the Molecular Biology of Cancer for undergraduates in Fudan University. His research works are supported by the grants from the National Natural Science Foundation of China, Shanghai Committee of Science and Technology, and Shanghai Municipal Health Bureau.

Talk Title: "A novel lncRNA associated with Taxol resistance in ovarian cancer"

Abstract: Ovarian cancer is the most lethal disease and the fifth leading cause of cancer death in women. One of the reasons for the low survival rate of patients with ovarian cancer is recurrence, partly resulted from the resistance of chemotherapy. Paclitaxel (Taxol) is the first line drug of ovarian cancer treatment and the mechanisms of acquired resistance to paclitaxel are not well understood. Currently we established a paclitaxel-resistant ovarian cancer cell line and through high-profile analyses of microarray data, we discovered a long non-coding RNA that is associated with paclitaxel resistance. The function and mechanism of a novel lncRNA are investigated.

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