Centre for Research on Biomolecular Interactions presents Prof. Jeff Chan, Department of Chemistry, Beckman Institute for Advanced Science and Technology.  

Title: Expanding the Chemical Toolbox for Acoustic-based Imaging of Cancer

Abstract: Many disease states are characterized by molecular level changes that occur before detectable symptoms have begun to manifest. To maximize treatment outcomes, it is essential to accurately detect such alterations at an early stage. Chemical probes designed to selectively image such molecular processes have the potential to aid in disease diagnosis and can also provide unique insights into disease progression. As an important step toward these goals we have developed a palette of activatable probes for photoacoustic imaging and apply these to visualize changes in the tumor microenvironment. Briefly, photoacoustic imaging is a state-of-the-art technique that generates ultrasound signals from light, which can be detected and converted into high-resolution 3D images. Since sound scattering is three orders of magnitude less than light in tissue, photoacoustic imaging can be employed to image up to 8 cm in depth while achieving micron resolution. To image deeper regions of the body in real-time, we have recently developed the first activatable ‘smart bubbles’ for ultrasound imaging. Like our photoacoustic probes, smart bubbles respond selectively to a disease property to provide signal enhancements via enhancement of their echogenic properties. In this seminar, we will discuss the strategies employed to construct both photoacoustic and ultrasound probes, as well as highlight notable examples from our laboratory.

Short Biography: Jeff Chan received his BSc degree in chemistry from the University of British Columbia in 2006 and his PhD from Simon Fraser University (Prof. Andrew Bennet) in 2011. For his graduate research, he received the Boehringer Ingelheim (Canada) Doctoral Research Award for the top Canadian thesis in the areas of organic and bioorganic chemistry. From 2011-2014 he was a Human Frontiers Science Program Postdoctoral Fellow at the University of California, Berkeley (Prof. Christopher Chang). In the fall of 2014, he joined the faculty at the University of Illinois, Urbana-Champaign and is currently an Associate Professor of Chemistry and the group leader of the photoacoustic imaging group at the Beckman Institute for Advanced Science and Technology.

Date: Wednesday, April 14,2021

Time: 2:00pm-3:00pm